Selected 2025
1. Engineering Complexity: Advances in 3D Breast Cancer Models for Precision Oncology.
Advanced Healthcare Materials, https://doi.org/10.1002/adhm.202503104
bioRxiv, https://doi.org/10.1101/2025.06.06.658360
Advanced Healthcare Materials, https://doi.org/10.1002/adhm.202402680
4. Bioprinting of Adipose Tissue Graft with Enhanced Neo-Vessel Formation in Vivo
Advanced Healthcare Materials, https://doi: 10.1002/adhm.202500627
5. A bio-printed breast cancer-adipose intact tissue model mimicking distance-dependent paracrine interaction to evaluate chemo- and adipokines-targeted therapies.
Advanced Healthcare Materials, https://doi.org/10.1002/adhm.202401887.
Book chapter
Body-on-a-Chip : Essentials and Applications 1 st Edition Chapter : 3D organ-on-a-chip for in vitro tissue modeling based on 3D bioprinting (Wiley Publishing)
All Research Information (Google Scholar)
Publications
Upcoming Publication
1. High throughput screening of patient-derived cancer organoids by improving physiological relevance with basement membrane matrix for clinical application (Under review_Acta Biomaterialia)
Jeong W., Kim D., Wajih N., Kang H.-W., Soker S., Lee S. J.,
Research summary : Triple-negative breast cancer (TNBC) is aggressive and influenced by basement membrane proteins. Using SOAR printing, TNBC spheroids with varying BM protein concentrations were developed, increasing stiffness and drug resistance. Higher BM levels led to greater cancer aggressiveness and reduced drug efficacy, enabling patient-specific drug response studies for personalized medicine in 7 days
2. Scalable 3D Bioprinting of Human Islets in a Pancreatic Decellularized Extracellular Matrix-Enriched Bioink for Beta-Cell Replacement Therapy
Jeong W., Perrier Q., Rengaraj A., Byers L., Asthana A., Lee S. J., Orlando G.
Research summary : Clinically applicable human islet constructs, bioprinted at 10,000 IEQ/mL, maintained viability and glucose-stimulated insulin secretion for 21 days, outperforming free islets. Optimized bioprinting parameters enabled low-shear extrusion using a human pancreas-derived dECM–alginate bioink, supporting the construct’s structural integrity, immunoprotection, and translational potential for β-cell replacement therapies.
3. Phenylboronic Acid–Dopamine Hybrid Copolymer Nanoparticles for Synergistic Chemodynamic, Starvation, and Diagnostic Therapy of Triple-Negative Breast Cancer
Jeong W., Lee K. K., Lee S. J., Lee S.
Research summary : MDA-MB-231, fibroblast, and muscle cells were 3D-bioprinted as spheroids for drug testing. A glucose-responsive nanoplatform selectively induced apoptosis in TNBC cells via CDT and ROS generation, as illustrated. Spheroids showed high viability and reproducibility, with selective cytotoxicity and metabolic reduction in TNBC, supporting targeted therapy evaluation.
4. Comparative Analysis of Local Anesthetic-Induced Myotoxicity and Attenuation Effect by Dexmedetomidine in an In Vitro 3D Human Skeletal Muscle Model
Jeong W., Choi H., Lee H.M., Lee S.
Research summary : Engineered muscle model exhibited self-alignment, forming multi-nucleated, uniformly oriented fibers, similar to native architecture. The model recapitulated drug-specific myotoxicity, with bupivacaine inducing pronounced cell death, metabolic dysfunction, and fiber deformation compared to ropivacaine. Co-treatment with dexmedetomidine significantly mitigated these effects, preserving viability, muscle fiber integrity, and ECM structure across both LAs.
5. Spatial Control of Platelet-Rich Plasma Enhanced Soft Tissue Engraftment with Uniform Vascular Infiltration
Mohamed H.J., Jeong W., Kim M.K., Choi J., Han J., Kang H.-W.
